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Target intelligence / Profile preview
Zinc finger protein 618 (ZNF618)
- Target
- ZNF618
- Molecular classification
- Transcription factor, Zinc finger protein, Chromatin-protein adaptor
01
Overview
Zinc finger protein 618 (ZNF618) is a human protein encoded by the ZNF618 gene and belongs to the zinc finger C2H2-type family of transcription factors. It acts primarily as a chromatin-protein adaptor, participates in protein dimerization, and is involved in the regulation of DNA-templated transcription. ZNF618 is noted for regulating the function and chromatin localization of UHRF2, a 5-hydroxymethylcytosine (5hmC) reader. Mutations or dysregulation of ZNF618 have been associated with various cancers, including mixed phenotype acute leukemia and nut midline carcinoma.
- Other names
- KIAA1952NEDD10neural precursor cell expressed developmentally down-regulated 10FP13169ZNF618
02
Biological functions
Regulation of DNA-templated transcriptionProtein dimerizationProtein bindingChromatin bindingChromatin localizationTranscription coregulation
03
Disease associations
Cancer (specifically mixed phenotype acute leukemia, nut midline carcinoma)Other
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