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Zinc finger protein 619 (ZNF619)
- Target
- ZNF619
- Molecular classification
- Transcription factor (zinc finger protein family), DNA-binding protein
01
Overview
Zinc finger protein 619 is a human DNA-binding transcription factor belonging to the zinc finger protein family. It is predicted to regulate gene expression by binding to specific DNA sequences and influencing transcription, primarily through RNA polymerase II. The protein contains zinc finger domains which stabilize its structure and mediate sequence-specific interactions with DNA. ZNF619 is encoded by a protein-coding gene expressed predominantly in the nucleus and is involved in transcriptional regulation. It has been linked (primarily by genetic association) to certain rare developmental disorders but is not established as a major therapeutic target or biomarker for human disease. Its expression has been studied in various tissues, including cancer, but its functional role in pathology remains unclear.
- Other names
- ZNF619FLJ90764
02
Biological functions
Regulation of transcription by RNA polymerase IISequence-specific DNA bindingGene expression control
03
Disease associations
Intellectual developmental disorder (autosomal recessive)Trichorhinophalangeal syndrome, type IIOther (no robust evidence of involvement in major cancers or as a driver gene, but expression profiled in cancer tissues)
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