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Zinc finger protein 629 (ZNF629)
- Target
- ZNF629
- Molecular classification
- Transcription factor, Zinc finger protein, Krueppel C2H2-type zinc-finger protein family
01
Overview
Zinc finger protein 629 (ZNF629) is a Krueppel C2H2-type zinc-finger transcription factor encoded by the ZNF629 gene in humans, located on chromosome 16p11.2. It is predicted to function primarily in the nucleus and is involved in the regulation of gene transcription by binding to DNA in a sequence-specific manner, acting as a transcription activator for genes transcribed by RNA polymerase II. ZNF629 belongs to a large family of zinc finger proteins that typically participate in the control of various cellular processes through modulation of gene expression. Disease associations include intellectual developmental disorders and neurodegenerative conditions, but there are no known drugs or therapeutic targeting mechanisms for this protein at present[1][2][3][4][7][9].
- Other names
- ZNF629ZNFZNF65KIAA0326zinc finger protein 65
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA bindingMetal ion (zinc) bindingDNA-binding transcription activator activityRNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity
03
Disease associations
Autosomal dominant intellectual developmental disorder 40Frontotemporal dementia and/or amyotrophic lateral sclerosis 7
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