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Zinc finger protein 639 (ZNF639)
- Target
- ZNF639
- Molecular classification
- Transcription factor, C2H2-type zinc-finger protein, Kruppel-like zinc finger family protein
01
Overview
Zinc finger protein 639 (ZNF639) is a member of the Kruppel-like C2H2-type zinc-finger protein family that binds DNA and may function as a transcriptional repressor[4][5][2]. Amplification and overexpression of ZNF639 have been observed in esophageal squamous cell carcinoma[3]. It has also been implicated in the regulation of HIV-1 gene expression and alternative splicing, resulting in multiple transcript variants[3]. The protein is primarily associated with gene regulation through DNA-binding transcription factor activity[3][5][2][4].
- Other names
- ZNF639ZASC1ANC-2H01Zinc finger protein ANC_2H01Zinc finger protein ZASC1zinc finger amplified in esophageal squamous cell carcinomas 1ANC_2H01
02
Biological functions
DNA bindingTranscriptional repressionRegulation of gene expression
03
Disease associations
Cancer (notably esophageal squamous cell carcinoma)Carotid body cancerRetinitis pigmentosa 51
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