Zinc finger protein 64 (ZFP64)

Zinc finger protein 64 is a DNA-binding transcription factor belonging to the zinc finger protein family, characterized by metal ion‐binding motifs that enable interaction with nucleic acids and proteins[3][4][5]. ZFP64 is implicated in the regulation of mesenchymal cell differentiation, acting as a downstream target of Runx2 via direct promoter transactivation, and serving as a coactivator of Notch1 to activate genes such as Hes1 and Hey1, hence influencing cell fate and tissue development[2][4][5]. Zinc finger proteins as a broader class play critical roles in transcription regulation, protein-protein interactions, and cellular responses to developmental and disease signals, particularly in oncogenesis and cell lineage determination[1][3][4]. Human ZFP64 is encoded on chromosome 20 and is present in cytoplasmic and nuclear compartments[4][5]. While other zinc finger proteins are established therapeutic and prognostic targets (especially in oncology), specific clinical applications and drug targeting for ZFP64 remain limited or under active investigation[1][4].

Other names

ZFP64ZNF338ZFP64 zinc finger protein

No detailed mechanism for drugs targeting ZFP64; mechanisms would likely involve modulation of transcriptional activity or interaction with Notch signaling