Target intelligence / Profile preview

Zinc finger protein 649 (ZNF649)

Target: ZNF649
Molecular classification: Transcription factor, Zinc finger protein

Overview

Zinc finger protein 649 is a human protein encoded by the ZNF649 gene located on chromosome 19. It functions primarily as a transcriptional repressor, regulating transcription factor complexes and suppressing SRE and AP-1 dependent transcription activities, which may be mediated by growth factor signaling pathways. ZNF649 is predicted to enable DNA-binding transcription factor activity and is involved in regulation of osteoblast differentiation and gene expression through RNA polymerase II. The protein is expressed in both the nucleus and cytoplasm across various human tissues.

Other names: ZNF649FLJ12644zinc finger protein 649

Biological functions

Regulation of transcription by RNA polymerase IINegative regulation of DNA-templated transcriptionRegulation of osteoblast differentiationTranscriptional repressionDNA-binding transcription factor activity

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