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Zinc finger protein 658 (ZNF658)
- Target
- ZNF658
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 658 (ZNF658) is a zinc-responsive transcription factor that represses transcription of genes, including SLC30A5, SLC30A10, and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) within their promoter regions. It regulates zinc homeostasis and plays a key role in coordinating ribosome biogenesis, which is a highly zinc-demanding cellular process, by controlling levels of ribosomal RNA and ribosomal proteins in accordance with cellular zinc availability. ZNF658 is predicted to localize to the nucleus and carries out its function by binding DNA and modulating gene expression, especially in response to zinc ion levels. Disease association has been reported with Hemoglobin H disease, but direct therapeutic targeting or drug interaction data is not currently available.
- Other names
- ZNF658MGC35232DKFZp572C163FLJ32813ZNF658phZNF658A0A087WVA2A0A087WZ36
02
Mechanism of action
Not established for drugs; ZNF658 itself represses target gene expression by binding to a zinc transcriptional regulatory element (ZTRE) in gene promoters
03
Biological functions
Transcriptional repression in response to zincRegulation of genes involved in zinc homeostasisControl of ribosome biogenesis by regulating rRNA and ribosomal protein levelsCellular response to zinc ionDNA binding
04
Disease associations
Associated with Hemoglobin H diseaseOther disease roles: not established
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