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Zinc finger protein 665 (ZNF665)
- Target
- ZNF665
- Molecular classification
- Transcription factor (specifically, a C2H2-type zinc finger protein)
01
Overview
Zinc finger protein 665 is a human protein encoded by the ZNF665 gene located on chromosome 19. It is a predicted DNA-binding transcription factor, probably functioning in the regulation of gene expression by RNA polymerase II. ZNF665 contains zinc finger domains, which mediate its interaction with DNA, enabling sequence-specific binding to cis-regulatory elements in target genes. There is currently limited information on its specific biological roles, regulated targets, or involvement in human disease, though genetic association with Fraser syndrome 1 and chronic laryngitis has been reported. No evidence currently supports its use as a therapeutic target or clinical biomarker[1][2][3][6][7].
- Other names
- ZNF665ZFP160LZinc finger protein 160-likeFLJ14345
02
Biological functions
Regulation of transcription by RNA polymerase IIDNA-binding transcription factor activity
03
Disease associations
Fraser syndrome 1 (association reported; mechanism and clinical significance unclear)Chronic laryngitis (association reported; mechanism and clinical significance unclear)
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