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Target intelligence / Profile preview
Zinc finger protein 681 (ZNF681)
- Target
- ZNF681
- Molecular classification
- Transcription factor, Zinc finger protein, KRAB domain-containing protein
01
Overview
Zinc finger protein 681 (ZNF681) is a protein encoded by the ZNF681 gene in humans. It contains both a Krueppel-associated box (KRAB) domain and multiple zinc-finger motifs, molecular features characteristic of a subclass of regulatory proteins known as transcription factors. ZNF681 is predicted to participate in transcriptional regulation by binding to nucleic acids, most likely DNA. Non-functional variants of the gene occur in some population genome assemblies. There is no resolved 3D structure for this protein. While ZNF681 has been associated with Dandy-Walker Syndrome, its underlying biological and disease roles remain poorly defined. No drugs targeting ZNF681 have been reported, it is not established as a biomarker, and there are currently no safety concerns or therapeutic applications known for this protein.
- Other names
- ZNF681FLJ31526hypothetical protein FLJ31526zinc finger protein 681
02
Biological functions
Transcriptional regulation (likely involved, based on domain structure and current annotation)Nucleic acid bindingDNA-binding transcription factor activity, RNA polymerase II-specific
03
Disease associations
Dandy-Walker Syndrome (association noted; no strong mechanistic role established)
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