Zinc finger protein 692 (ZNF692)

Zinc finger protein 692 (ZNF692) is a DNA-binding transcription factor belonging to the Krueppel C2H2-type zinc finger protein family[1][2][5]. It is primarily involved in the negative regulation of transcription by RNA polymerase II and plays a key role in hepatic gluconeogenesis through transcriptional repression of the phosphoenolpyruvate carboxykinase (PCK1) gene, under the regulation of AMPK signaling—phosphorylation at Ser-470 diminishes its DNA binding affinity[1][2][5]. ZNF692 is highly expressed in multiple tissues and localizes to the nucleolus and nucleoplasm[1][2][6]. Beyond metabolism, ZNF692 has emerged as an oncogenic driver in multiple tumors, where its overexpression promotes cell proliferation, migration, invasion, and poor prognosis, mainly through the PI3K/AKT and related signaling pathways[1]. It also interacts with nucleophosmin 1, influencing nucleolar morphology and protein synthesis[1]. Currently, there are no approved drugs that directly target ZNF692, but its expression is a potential biomarker in oncology[1][5].

Other names

AREBPZFP692AICAR responsive element binding proteinFLJ20531Zfp692

not applicable (no known direct pharmacological modulators; participates in metabolic and oncogenic signaling pathways)