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Zinc finger protein 699 (ZNF699)
- Target
- ZNF699
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 699 (ZNF699) is a human protein encoded by the ZNF699 gene on chromosome 19p13[1][3]. It is a putative transcription factor in the zinc finger protein family, predicted to bind DNA and regulate the transcription of genes via RNA polymerase II[2][3][5]. ZNF699 is the human ortholog of the Drosophila hang (hangover) gene, which has been studied for its role in alcohol tolerance in flies; in humans, variants in ZNF699 have been associated with susceptibility to alcohol dependence[2]. Pathogenic variants in ZNF699 cause a rare genetic disorder known as Developmental Delay with Gastrointestinal, Cardiovascular, Genitourinary, and Skeletal Abnormalities (DEGCAGS syndrome), which presents with multisystem developmental anomalies[4]. ZNF699 is not currently considered a therapeutic target, and no specific drugs are known to interact with this protein.
- Other names
- FLJ38144HANGhangover homologDEGCAGSHangZinc finger protein 699hangover
02
Biological functions
Regulation of transcription by RNA polymerase II (predicted)DNA-binding transcription factor activity (predicted)
03
Disease associations
Developmental Delay with Gastrointestinal, Cardiovascular, Genitourinary, and Skeletal Abnormalities (DEGCAGS syndrome)Intellectual disability (non-specific syndromic)Alcohol dependence, association (genetic association studies)
04
Biomarkers
Genetic variants in ZNF699 (as risk/susceptibility markers for alcohol dependence in some human populations)ZNF699 mutation (DNV) in DEGCAGS syndrome diagnosis
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