Zinc finger protein 732 (ZNF732)

Zinc finger protein 732 is a member of the Kruppel-associated box-containing zinc finger protein (KRAB-ZFP) family, which are among the largest families of mammalian transcriptional repressors[1][4]. It contains an N-terminal KRAB domain and sixteen C-terminal C2H2-type zinc finger domains, which enable it to bind nucleic acids and modulate gene expression through transcriptional repression, typically via recruitment of the KRAB-associated protein 1 (KAP1) cofactor and engagement with histone modifiers to induce heterochromatin formation[1]. The gene is protein coding and located on human chromosome 4. ZNF732’s specific biological functions remain incompletely characterized, but it is predicted to participate in gene expression regulation, like other KRAB domain zinc finger proteins[1][5]. No direct links to common therapeutic applications or established drug interactions have been reported, and it is not classified as a therapeutic target. The only disease noted in association is Three M syndrome 1[1]. Key points: - ZNF732 is a **transcription factor** of the KRAB-ZFP family, not a canonical therapeutic target such as a receptor or enzyme[1][4][5]. - Also known by aliases including FLJ59067 and zinc finger protein LOC654254[1][3]. - Functions in nucleic acid binding and negative regulation of transcription, though specific target pathways and disease relationships are not yet well defined[1][4][5]. - Not currently associated with interacting drugs, mechanisms of action for drugs, or a role as a biomarker or in therapeutic safety concerns.

Other names

FLJ59067ZNF732zinc finger protein LOC654254zinc finger protein 732