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Zinc finger protein 76 (ZNF76)
- Target
- ZNF76
- Molecular classification
- Transcription factor, Zinc finger protein, Krueppel C2H2-type zinc-finger protein family
01
Overview
Zinc finger protein 76 (ZNF76) is a DNA-binding transcription factor in the Krueppel C2H2-type zinc finger protein family[3][4][6]. It acts as a general transcriptional repressor, targeting TATA-binding protein (TBP), and its activity is regulated by post-translational modifications such as sumoylation and acetylation[2][7]. ZNF76 is predicted to play roles in the positive and negative regulation of gene transcription, particularly in central nervous system and embryonic development, with important expression in the brain, eyes, and midbrain–hindbrain boundary during embryogenesis[2]. Despite its clear function as a transcriptional regulator, there are currently no established roles for ZNF76 as a therapeutic target, nor any drugs that act on it. Additionally, some confusion exists in alias names, as ZNF523 and ZNF76 are separate genes/proteins[3]; this target's aliases should omit "ZNF523" and related Zfp523 entries.
- Other names
- ZNF76D6S229EZinc finger protein 76 (expressed in testis)znf76 (mouse, zebrafish ortholog)
02
Biological functions
DNA-binding transcription factor activityTranscriptional regulationRepression of transcription (interacts with TATA-binding protein, TBP, and regulated by sumoylation/acetylation)Regulates gene expression in brain, midbrain-hindbrain boundary, embryonic development
03
Disease associations
Other (no direct, well-established links to major disease groups like cancer, inflammation, neurodegeneration, cardiovascular, or infection)Potential but unconfirmed developmental roles
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