Zinc finger protein 765 (ZNF765)

Zinc finger protein 765 (ZNF765) is a member of the zinc finger protein family, characterized by containing multiple C2H2-type zinc finger domains that enable DNA binding and transcriptional regulation[1][3][5]. ZNF765 is encoded on human chromosome 19q13.42 and is predicted to act as a sequence-specific transcription factor, primarily active in the nucleus, regulating RNA polymerase II-mediated transcription[5]. It has been implicated in cancer, with higher expression levels correlating with poor prognosis and increased immune cell infiltration in hepatocellular carcinoma[2]. ZNF765 also binds to specific retroelement sequences and may repress the transcription of inactive retrotransposons[4]. As a biomarker, its methylation and RNA modification status may play roles in tumor progression and therapy stratification[2]. There are no documented direct small-molecule or biological drugs targeting ZNF765, but its pivotal functions in gene expression and cancer make it of therapeutic interest as a potential target or biomarker[2][5].

Other names

ZNF765zinc finger protein 765ZN765_HUMAN

Not directly targeted by drugs; possible indirect mechanisms may involve modulation of transcription and chromatin structure