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Zinc finger protein 778 (ZNF778)
- Target
- ZNF778
- Molecular classification
- Transcription factor, Zinc finger protein (Krueppel C2H2-type)
01
Overview
Zinc finger protein 778 is a transcription factor belonging to the Krueppel C2H2-type zinc-finger protein family, characterized by a KRAB domain and eighteen C2H2-type zinc fingers[1][3][5]. It regulates gene expression through sequence-specific DNA binding, is implicated as a candidate gene in autism and cognitive impairment associated with the 16q24.3 microdeletion syndrome, and may play roles in cancer biology and immunity based on functional knockout models[1][3][7]. Evidence for drug interactions, clinical targeting, or use as a biomarker in therapeutic settings is lacking in current literature.
- Other names
- Zinc finger protein 778ZNF778FLJ31875LOC105376780
02
Biological functions
Regulation of gene expression (transcriptional regulation)DNA binding
03
Disease associations
Neurodevelopmental disorder (candidate gene for autism)Variable cognitive impairment (notably in 16q24.3 microdeletion syndrome)Possible roles in cancer biology (based on research model context)
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