Zinc finger protein 787 (ZNF787)

Zinc finger protein 787 is a human transcription factor characterized by multiple zinc finger domains. Experimental studies suggest ZNF787 acts as a negative regulator of tight junction proteins such as occludin and claudin-5, particularly in the context of increased blood-brain barrier permeability in Alzheimer's disease models. Mechanistic data indicate ZNF787 interacts with HDAC1 to suppress transcription of tight junction genes, thereby modulating blood-brain barrier integrity and inflammation. ZNF787 may also be involved in genetic fusion events in cancer, but is not established as a direct therapeutic target.

Other names

TTF-I-interacting peptide 20TIP20transcription termination factor I interacting peptide 20ZNF787

Not applicable (No drugs targeting ZNF787 have been described; its own function is transcriptional regulation, particularly repressing tight junction genes through HDAC1 interaction)