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Target intelligence / Profile preview
Zinc finger protein 8 (ZNF8)
- Target
- ZNF8
- Molecular classification
- Transcription factor, Zinc finger protein
01
Overview
Zinc finger protein 8 is a DNA-binding transcription factor predicted to act as a transcriptional repressor and negatively regulate transcription by RNA polymerase II[1][2][6][3]. It may play roles in BMP and TGF-beta signal transduction through its interaction with SMAD proteins. ZNF8 has been implicated in several diseases, including hypogonadotropic hypogonadism 12 with or without anosmia and the progression of gastrointestinal cancers in a p53-dependent manner, but is not currently considered a direct therapeutic target[1][6][7].
- Other names
- Zinc finger protein 8ZNF8HF.18Zfp128Zinc finger protein HF.18zinc finger protein 272zinc finger protein 8 (clone HF.18)zinc finger protein HF.18
02
Biological functions
Negative regulation of transcription by RNA polymerase IIRegulation of transcription (DNA-templated)May modulate BMP and TGF-beta signal transduction through interaction with SMAD proteins
03
Disease associations
Hypogonadotropic hypogonadism 12 with or without anosmiaCancer (specifically, progression of gastrointestinal cancers via a p53-dependent mechanism)
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