Zinc finger protein 816 (ZNF816)

Zinc finger protein 816 (ZNF816) is a transcription factor encoded by the ZNF816 gene on human chromosome 19q13.41[1][4][5]. It contains a Krüppel-associated box (KRAB) domain and an array of 15 C2H2 zinc finger motifs, enabling it to bind DNA and repress transcription by recruiting co-repressors that promote heterochromatin formation[1][2][3]. ZNF816 is broadly expressed in many human tissues, localizes predominantly in the nucleus, and interacts with other proteins involved in transcriptional regulation, protein ubiquitination, and DNA repair (e.g., TRIM28, CUL3)[1]. While direct associations with specific diseases remain under study, ZNF816 variants have been implicated as candidates in emphysema, Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome, and early-onset psoriasis[1]. No drugs are currently known to interact directly with ZNF816, nor is it established as a recognized therapeutic target[4].

Other names

ZNF816Azinc finger protein 816A