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Zinc finger protein 845 (ZNF845)
- Target
- ZNF845
- Molecular classification
- Transcription factor, Zinc finger protein (C2H2-type)
01
Overview
Zinc finger protein 845 (ZNF845) is a novel transcription factor containing six tandem C2H2 zinc finger domains, first identified in cnidarians such as Hydra and Nematostella vectensis. It plays a crucial developmental role by promoting the differentiation of cnidocytes—the specialized stinging cells unique to cnidarians—while inhibiting the neural fate in embryonic development. ZNF845 functions as a key upstream regulator in the cnidocyte lineage, acting before expression of PaxA and other cnidocyte-specific transcription factors. It is one of several zinc finger proteins that arose in early animal evolution and does not have any direct orthologs or known regulatory functions in humans[1][2][3].
- Other names
- ZNF845zinc finger protein 845
02
Mechanism of action
Biologically, ZNF845 acts upstream of PaxA and other markers in the cnidogenesis pathway, promotes cnidocyte (stinging cell) differentiation, and inhibits neural lineage, in part through regulation of nuclear receptor NR12
03
Biological functions
Regulation of cell fate and differentiation (specifically, promoting cnidocyte fate and inhibiting neural fate in cnidarian embryos)DNA-binding, transcriptional regulation
04
Disease associations
Involved in cell fate specification in cnidarians
05
Biomarkers
Molecular marker for cnidocyte fate in cnidarian research
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