Zinc finger protein 862 (ZNF862)

Zinc finger protein 862 (ZNF862) is a protein encoded by the ZNF862 gene located on chromosome 7q36.1 in humans[2][7]. It encodes a 1169-amino acid protein characterized by multiple zinc finger domains, including the C2H2-type zinc fingers, a krüppel-associated box (KRAB) domain, a ZnF_TTF domain, and a Dimer_Tnp_hAT (hAT family C-terminal dimerization region) domain[2]. It is a predicted intracellular protein involved in the regulation of DNA-templated transcription, likely functioning as a transcriptional repressor. Experimental studies have shown that pathogenic variants in ZNF862 cause autosomal-dominant hereditary gingival fibromatosis (HGF), a condition characterized by gingival (gum) overgrowth due to increased production of profibrotic factors, notably COL1A1[2]. ZNF862 is predicted to participate in metal ion binding, protein dimerization, and may induce cytostasis and apoptosis, potentially via the p21-RB1 and Bcl-xL-Caspase 3 pathways[2][7]. Its expression is ubiquitous, and its biological roles may extend to other conditions such as Long QT syndrome and matrix-producing neoplasms[1][2]. However, ZNF862 is not currently considered a validated therapeutic target, and there are no known drugs that specifically interact with it.

Other names

KIAA0543GINGF6ZNF862