Zinc finger protein 879 (ZNF879)

Zinc finger protein 879 (ZNF879) is a KRAB (Kruppel-associated box)-containing C2H2-type zinc finger protein that functions as a DNA-binding transcription factor and transcriptional repressor[1]. It contains an N-terminal KRAB domain—enabling the recruitment of KRAB-associated protein 1 (KAP1), which in turn engages histone modifiers to induce heterochromatin formation—and thirteen C2H2-type zinc finger domains for DNA interaction[1][3]. ZNF879 is a member of the largest family of mammalian transcriptional repressors, typically acting to regulate gene expression and chromatin structure[1][3]. The specific physiological roles or disease associations of ZNF879 itself remain unclear, but related zinc finger proteins mediate diverse regulatory functions in development and differentiation[3][5]. Notes: - Current evidence does not support ZNF879 as a therapeutic target or receptor; it is primarily classified as a transcriptional repressor in the zinc finger family[1][3][5]. - There is currently no evidence for direct drug interactions, validated disease roles, or biomarker/safety information specific to ZNF879[1][3]. - Functionally, ZNF879 shares typical molecular features and activities with the broader KRAB-ZFP subfamily of C2H2 zinc finger transcription factors[1][3].

Other names

ZNF879DKFZp686E2433novel zinc finger proteinzinc finger protein 879