Zinc finger protein interacting with K protein 1 (ZIK1)

Zinc finger protein interacting with K protein 1 (ZIK1) is a protein featuring nine C2H2-type zinc finger motifs in its C-terminus and a KRAB-A (Krüppel-associated box-A) domain. Its main biological function is to bind specific DNA elements in the nucleus and repress transcription via interactions with chromatin and other nuclear proteins, such as heterogeneous nuclear ribonucleoprotein K (hnRNP K). ZIK1 interacts directly with K protein and can modulate gene expression by serving as a docking partner or regulator in signal transduction and gene expression pathways. Although ZIK1 shares structural similarities with other zinc finger transcriptional repressors, it is not considered a classical therapeutic drug target and has not been implicated directly in disease mechanisms besides some association with Goldberg-Shprintzen syndrome. As a general member of the zinc finger protein family, it participates in a wide range of DNA and protein interactions, thus contributing to the regulation of transcription and cellular identity.

Other names

Zinc finger protein interacting with ribonucleoprotein KZIK1ZNF762zinc finger protein 762zinc finger protein interacting with K protein 1 homolog