Zinc finger protein Rlf (RLF)

Zinc finger protein Rlf (RLF) is a human transcription factor encoded by the RLF gene, located on chromosome 1. It contains 15 C2H2-type zinc finger domains that enable DNA binding and activation of gene transcription, specifically through RNA polymerase II. RLF is closely related to ZNF292, sharing significant homology, especially at the N-terminus. Its biological roles include the regulation of transcription and chromatin structure, as well as protein-protein interactions through its zinc finger motifs. It has been implicated in cell maintenance, epigenetic regulation (hypomethylation of CpG shores at gene promoters), and disease processes such as cancer and neurodevelopmental disorders. RLF is localized to the nucleus but may also be present in extracellular exosomes. No drugs directly target RLF, and therapeutic modulation remains a technical challenge due to its molecular nature as a transcription factor.

Other names

ZNF292LZn-15LRearranged L-myc fusion gene proteinZn-15-related proteinZN-15Lzinc finger protein RlfZn-15 relatedrearranged L-myc fusion gene proteinrearranged L-myc fusion sequencezn-15-related proteinRLF

None currently annotated or described for this protein; in theory, mechanisms would involve modulation of DNA binding or protein-protein interactions, but such approaches have not reached clinical use