Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4)

Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4) is a transcription factor from the C2H2 zinc finger protein family. It is characterized by KRAB and SCAN domains, which confer abilities for transcriptional repression and protein-protein interactions. ZKSCAN4 binds DNA in a sequence-specific manner, regulating gene expression—especially through RNA polymerase II. It has roles in chromatin remodeling and can impact cellular stress responses. Research indicates ZKSCAN4 affects synaptic function and resilience to chronic stress in the hippocampus, and may contribute to psychiatric disorders and cancer progression. While it is recognized as a potential therapeutic target due to its involvement in key transcriptional axes, no approved drugs or clinical biomarkers directly target ZKSCAN4[1][2][3][4][5][6].

Other names

ZNF307ZNF427ZSCAN36p373c6.1P1P373C6FLJ32136zinc finger protein 307zinc finger protein 427Zinc finger protein with KRAB and SCAN domains 4ZKSCAN4

Not applicable for any approved drugs; in principle, inhibition or activation could modulate its transcriptional regulatory activity (e.g., targeted inhibition could upregulate ZKSCAN4-repressed genes such as Htr2a)