Zinc finger protein with KRAB and SCAN domains 5 (ZKSCAN5)

Zinc finger protein with KRAB and SCAN domains 5 (ZKSCAN5) is a member of the zinc finger protein family characterized by the presence of a C2H2-type zinc finger DNA-binding domain, a KRAB domain (Krüppel-associated box), and a SCAN domain[1][2]. These combined domains endow ZKSCAN5 with the ability to act as a transcription factor, binding DNA and modulating gene expression in various cellular contexts[1][2]. Zinc finger proteins like ZKSCAN5 are the largest family of transcription factors in the human genome and are involved in the regulation of numerous biological processes, including cell differentiation, apoptosis, immune responses, and metabolism[1][3]. While ZKSCAN5 itself is not broadly validated as a therapeutic target, the larger family of KRAB and SCAN domain-containing zinc finger proteins has established roles in cancer biology, with some members acting as oncogenes or tumor suppressors, and several serving as prognostic markers in cancer such as hepatocellular carcinoma[1]. The specific functional impact of ZKSCAN5 in disease or therapy remains less defined, with no known therapies directly targeting this protein[1]. Key points: - Protein class: Transcription factor (C2H2 zinc finger, KRAB and SCAN domains) - Function: Regulates gene expression by DNA binding; possible interaction with other proteins/RNAs - Disease role: Implicated in cancer through the broader family; ZKSCAN5-specific disease mechanisms not clearly defined - Therapeutic status: Not a well-established therapeutic target; no known interacting drugs or direct clinical safety issues[1][2][3]

Other names

KIAA1015ZFP95Zfp-95ZNF914ZSCAN37Zinc finger protein 95 homologzinc finger protein homologous to Zfp95 in mouse