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Zinc finger SWIM-type containing 5 (ZSWIM5)
- Target
- ZSWIM5
- Molecular classification
- Zinc finger protein, SWIM domain-containing protein, Other (potential ubiquitin ligase complex component)
01
Overview
Zinc finger SWIM-type containing 5 (ZSWIM5) is a protein containing the SWIM (CxCxnCxH) domain, a zinc-chelating motif that suggests involvement in DNA or protein interactions typical for zinc finger proteins[1][2][4]. It is predicted to bind zinc ions and is found primarily in the nucleus and cytoplasm. ZSWIM5 shows reduced expression in non-small-cell lung cancer, acting as a tumor suppressor by inhibiting cancer cell proliferation, invasion, and migration—largely through the downregulation of cyclins and matrix metalloproteinases[2]. It is classified as a member of the zinc finger protein family with possible involvement in Cullin-RING E3 ubiquitin ligase complexes[1][3], though details of additional interacting proteins, drugs, or therapeutic targeting remain unknown. Reduced ZSWIM5 expression is associated with advanced cancer stage, metastasis, and poorer prognosis in NSCLC patients[2].
- Other names
- Zinc finger SWIM domain-containing protein 5KIAA1511zinc finger, SWIM-type containing 5zswim5 (zebrafish ortholog)
02
Biological functions
Zinc ion bindingRegulation of cell cycle (via cyclin proteins)Potential E3 ubiquitin ligase complex participantInhibition of cancer cell proliferation, invasion, and migration
03
Disease associations
Cancer (specifically implicated as a tumor suppressor in non-small-cell lung cancer)
04
Biomarkers
Loss of ZSWIM5 expression as a prognostic biomarker for poor outcome in non-small-cell lung cancer
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