Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Zinc finger SWIM-type containing 6 (ZSWIM6)
- Target
- ZSWIM6
- Molecular classification
- Zinc finger protein, SWIM-type domain protein, DNA-binding protein, Other
01
Overview
Zinc finger SWIM-type containing 6 (ZSWIM6) encodes a highly conserved zinc finger protein with a SWIM (SWI2/SNF2 and MuDR) domain that is predicted to interact with DNA or proteins. It is critical for embryonic development, particularly the formation of craniofacial structures, the brain, and limbs. Variants in the gene are associated with disorders such as acromelic frontonasal dysostosis (characterized by frontonasal dysplasia, midline brain anomalies, and limb malformations) as well as neurodevelopmental syndromes. Functional studies show ZSWIM6 is expressed throughout the nervous system during early development, and its disruption is linked to altered Hedgehog pathway signaling and neuronal differentiation. Currently, there are no approved drugs targeting ZSWIM6, and it is not considered a classical therapeutic target, but rather a protein of developmental and genetic interest.
- Other names
- AFNDNEDMAGAZSWIM6_HUMAN
02
Biological functions
Nervous system developmentCraniofacial developmentLimb developmentRegulation of gene expressionDNA/protein bindingOther
03
Disease associations
Craniofacial malformation (acromelic frontonasal dysostosis)Neurodevelopmental disorder with movement abnormalities, abnormal gait, autistic featuresSevere intellectual disability (with specific variants)Other
04
Safety considerations
Not applicable; not a therapeutic target or druggable protein (no known drugs)
05
Biomarkers
Genetic mutations in ZSWIM6 as biomarkers for acromelic frontonasal dysostosis and neurodevelopmental disorders
Beyond the preview
Go deeper on Zinc finger SWIM-type containing 6 (ZSWIM6).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Zinc finger SWIM-type containing 6 (ZSWIM6).