Zinc finger SWIM-type containing 7 (ZSWIM7)

Zinc finger SWIM-type containing 7 (ZSWIM7) is a zinc finger protein characterized by the presence of a SWIM domain, facilitating zinc ion binding and protein-protein interactions[1][2]. ZSWIM7 is a critical component of the Shu complex and is predicted to be involved in the high-fidelity repair of double-stranded DNA breaks by homologous recombination, a process essential for genome stability during gametogenesis[1][2]. Both human and animal studies have shown that mutations in ZSWIM7 impair meiotic DNA repair, linking this gene with clinical phenotypes such as non-obstructive azoospermia and primary ovarian insufficiency, thereby implicating it in both male and female infertility[1][2]. ZSWIM7 is widely expressed across many tissues but with specific functional importance in the gonads, where its disruption compromises reproductive function. No direct evidence is available as of 2025 for therapeutic drugs, mechanisms of action, or substantive safety concerns related to ZSWIM7. Its main significance currently lies in genetic and reproductive health contexts.

Other names

SWS1SWIM domain-containing and Srs2-interacting protein 1 homologSWIM-type zinc finger domain-containing protein 7Zinc finger SWIM domain-containing protein 7SWIM domain containing Srs2 interacting protein 1ODG10SPGF71