Zinc finger SWIM-type containing protein 3 (ZSWIM3)

Zinc finger SWIM-type containing protein 3 (ZSWIM3) is a protein encoded by the ZSWIM3 gene in humans[1][3][7]. It belongs to the zinc finger SWIM-type protein family, characterized by the presence of a SWIM (SWI2/SNF2 and MuDR) zinc-binding domain[9]. This protein is predicted to bind zinc ions[1][3]. Its exact biological function is not fully characterized, but gene ontology annotations suggest possible roles in transposase activity and protein regulation[1]. ZSWIM3 does not have experimentally validated roles in signaling, cell cycle, apoptosis, or major disease processes. No known drugs, mechanisms of action, or clinical biomarker utilities are defined for this protein. There is no evidence as of 2025 that ZSWIM3 itself is a therapeutic target or is directly implicated in human disease. Key facts: - **SWIM-type zinc finger** proteins are DNA-binding motifs found in many regulatory proteins, but ZSWIM3’s specific cellular role remains largely uncharacterized[1][9]. - Aliases include historical gene IDs such as C20orf164 and PPP1R174, and it is also referred to as a protein phosphatase 1 regulatory subunit by annotation, but no functional evidence connects it to phosphatase regulation in humans as of current data[1]. - ZSWIM3 is conserved across species including humans and mice[10], but experimental evidence for its function, interaction partners, or role in disease is lacking. If detailed involvement in signaling pathways, drug targeting, or pathology is identified in future research, these categories would require updating accordingly.

Other names

C20orf164PPP1R174dJ337O18.7Zinc finger SWIM domain-containing protein 3Protein phosphatase 1 regulatory subunit 174

None known (no drugs defined to target or interact with ZSWIM3)