Zinc finger with KRAB and SCAN domains 1 pseudogene (ZKSCAN1 pseudogene)

Zinc finger with KRAB and SCAN domains 1 pseudogene (ENSG00000255530) is a genomic locus annotated as a pseudogene, not encoding a functional protein. It derives from the family of zinc finger proteins that typically contain both KRAB (a transcriptional repressor domain) and SCAN (a domain involved in protein-protein interaction) motifs, but as a pseudogene, it lacks protein-coding function and is not relevant as a drug target. The protein-coding parent gene (ZKSCAN1) is a member of a large family of transcriptional regulators, but this specific pseudogene does not participate in transcriptional regulation or cellular processes and is not implicated in disease or drug interactions. KRAB-ZNF and SCAN domain-containing genes are a large family of transcriptional regulators in tetrapods, often involved in gene repression and DNA binding, but pseudogenes in this family are typically non-functional, resulting from gene duplication and decay. Pseudogenes can sometimes act via regulatory RNA, but for this locus, no such functional evidence is available. The protein-coding ZKSCAN1 (not the pseudogene) is studied in transcriptional regulation, but the pseudogene does not share these biological roles. In summary: ENSG00000255530 is not a true functional molecule/receptor and should not be considered a therapeutic or biological target. If you are interested in the functional zinc finger KRAB-SCAN protein (ZKSCAN1), that would correspond to a different ENSG identifier and record.

Other names

ZKSCAN1 pseudogeneENSG00000255530