Zinc finger with KRAB and SCAN domains 7 (ZKSCAN7)

Zinc finger with KRAB and SCAN domains 7 (ZKSCAN7) is a member of the ZSCAN family of transcription factors, characterized by the presence of C2H2-type zinc finger motifs, a Krüppel-Associated Box (KRAB) domain, and a SCAN protein interaction domain[1][3][5]. ZKSCAN7 is mainly involved in transcriptional regulation, where it likely acts as both a transcriptional activator and repressor depending on interacting partners and context. The SCAN domain enables protein-protein interactions and the formation of homodimers or heterodimers within the ZSCAN family[5], while the KRAB domain typically recruits cofactors for transcriptional repression. ZKSCAN7 is expressed in human cells, with a molecular weight of approximately 85 kDa[1]. The zinc finger protein family, particularly those with KRAB and SCAN domains, are heavily implicated in the fine-tuning of gene expression networks, cell differentiation, development, immune response regulation, and cancer progression. The specific biological and disease roles of ZKSCAN7 are still under investigation, with current evidence suggesting relevance in cancer biology, but no direct therapeutic agents, mechanisms, or biomarkers identified at this time[3][5].

Other names

ZKSCAN7Zinc finger protein 167ZNF167Zinc finger protein 448ZNF448Zinc finger protein 64ZNF64FLJ12738ZSCAN39ZFP