Target intelligence / Profile preview

Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1)

Target: ZZEF1
Molecular classification: Histone reader, Transcriptional coregulator, Other (specifically, multi-domain protein including zinc finger and EF-hand domains)

Overview

Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1) is a multidomain protein characterized by the presence of ZZ-type zinc finger and EF-hand motifs. It functions primarily as a histone H3 reader, binding to the N-terminus of histone H3 and recognizing various epigenetic modifications on the H3 tail. ZZEF1 serves as a transcriptional coregulator, particularly by interacting with Krüppel-like factors KLF6 and KLF9 and modulating the expression of their target genes. The protein is implicated in chromatin organization, transcriptional regulation, and possibly neuronal and visual processes. Mutations in ZZEF1 have been associated in the literature with diseases such as diabetes and certain cancers, but it is not currently considered a direct therapeutic target such as a receptor, enzyme, or transporter

Other names: ZZEF1KIAA0399ZZZ4FLJ10821zinc finger, ZZ-type with EF hand domain 1

Biological functions

Chromatin organizationHistone binding (specifically, histone H3 reader)Transcriptional coactivation (notably with Krüppel-like factors KLF6 and KLF9)Potential regulation of glutamatergic synaptic transmissionRegulation of peptidyl-tyrosine phosphorylationVisual learning

Disease associations

CancerDiabetesOther (broad involvement in disease suggested, but specific roles mainly noted for some cancers and diabetes)

Beyond the preview

Go deeper on Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1).

Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.

Drug pipeline

Explore the programs pursuing this target and their development progress.

Drug candidates
Developers
Development stage

Clinical trials

Follow the clinical studies evaluating therapies directed at this target.

Trial design
Status
Readouts

Competitive landscape

Compare approaches across drug candidates, modalities, and indications.

Programs
Modalities
Indications

Literature & evidence

Investigate the research and source evidence behind target biology and development.

Publications
Sources
Analysis

Patents

Explore patent activity around therapies and technologies addressing this target.

Patents
Assignees
Technologies

Research & analysis

Connect target biology, drug development, and emerging evidence in your research.

Biology
Development news
Analysis

Bring the full picture into focus.

See how Gosset can support your research on Zinc finger ZZ-type and EF-hand domain-containing protein 1 (ZZEF1).

Explore the full profile