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Zinc Ion (Zn²⁺)
- Target
- Zn²⁺
- Molecular classification
- Inorganic Ion, Cofactor
01
Overview
The zinc ion (Zn²⁺) is the divalent cation form of the element zinc. It is an essential micronutrient that plays vital roles in biological systems as a cofactor for numerous enzymes, a structural component of proteins (e.g., zinc fingers), and in cellular signaling. Zinc is redox-inert and primarily coordinates with oxygen, nitrogen, and sulfur atoms in proteins. It is used therapeutically to inhibit copper absorption in conditions like Wilson's disease. Zinc deficiency can lead to various health problems, including growth retardation and immune dysfunction.
- Other names
- Zn(II)Zinc(2+)Zinc cation
02
Mechanism of action
Zinc ions act as enzyme cofactors, stabilize protein structure, and are involved in cellular signaling. Therapeutically, zinc can inhibit copper absorption.
03
Biological functions
Enzyme cofactorStructural role in proteinsRegulatory/SignalingTransport/Storage
04
Disease associations
Zinc deficiency related disordersWilson's disease (therapeutic use)
05
Safety considerations
Zinc toxicity (excessive intake)Drug interactions (e.g., with certain antibiotics)Gastrointestinal side effects (with high doses)
06
Interacting drugs
Zinc supplements
2 more in the full profile.
07
Biomarkers
Serum zinc levels (for deficiency)Urinary zinc levels
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