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Zinc Ion Homeostasis
- Molecular classification
- Biological Process
01
Overview
Zinc ion homeostasis encompasses all molecular machinery responsible for maintaining optimal intracellular/extracellular concentrations of Zn²⁺ through coordinated action by transporter families (ZnT/ZIP), metallothioneins for buffering/storage/detoxification purposes along with regulatory feedback loops involving transcriptional/post-translational modifications. Disruptions contribute significantly to disease pathogenesis across multiple physiological systems.
- Other names
- Zinc homeostasisIntracellular zinc ion homeostasisGO:0006882GO:0055069
02
Biological functions
Maintenance of zinc ion concentrationRegulation of zinc ion levelsZinc storageZinc detoxificationZinc transport
03
Disease associations
NeurodegenerationImmune dysfunctionMetabolic disordersObesity-related oxidative stressDiabetes mellitus complications
04
Safety considerations
Zinc deficiencyZinc toxicity
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