Target intelligence / Profile preview

Zinc Ion Transporters (N/A)

Target
N/A
Molecular classification
Transporter, Membrane protein, SLC30 family (ZnT), SLC39 family (ZIP)
01

Overview

Zinc ion transport encompasses all molecular processes governing selective movement of Zn²⁺ via dedicated transporter families—primarily SLC30/ZnTs for efflux/sequestration and SLC39/ZIPs for influx—with crucial roles in health maintenance at cellular through organismal levels. These transporters regulate cytosolic free Zn²⁺ levels, zinc storage within organelles, and zinc-dependent signaling pathways. Disruption in their function leads to diseases related to both deficiency and toxicity due to improper distribution.

Other names
Zinc transportersZnT family (SLC30)ZIP family (SLC39)Solute carrier family 30Solute carrier family 39
02

Mechanism of action

Modulation of zinc ion influx or efflux

03

Biological functions

Zinc ion transportRegulation of intracellular zinc concentrationZinc homeostasisZinc storageZinc-dependent signaling
04

Disease associations

NeurodegenerationDiabetesImmune dysfunctionDevelopmental disordersCancer
05

Safety considerations

Potential for zinc deficiency or toxicityOff-target effects on other metal ions

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