Zinc-regulated GTPase metalloprotein activator 1B (ZNG1B)

Zinc-regulated GTPase metalloprotein activator 1B (ZNG1B) is a conserved vertebrate metallochaperone enzyme that regulates cellular zinc homeostasis. It activates metalloproteins by directly transferring zinc cofactors, specifically catalyzing zinc insertion into their active sites. ZNG1B is predicted to bind GTP, hydrolyze GTP, and bind metal ions, and may be located in the nucleus. Deficiency or dysfunction could potentially disrupt zinc-dependent cellular processes, though no clear disease associations are currently described. No evidence for misidentification, and canonical synonyms and classification match established databases. There are currently no known therapeutic agents that directly act on this target, nor associated safety concerns, biomarkers, or drugs established in clinical use. However, its function in zinc homeostasis may have broad biological significance.

Other names

Cobalamin synthase W domain-containing protein 2CBWD2ZNG1B (gene symbol)