Zinc-regulated GTPase metalloprotein activator 1F (ZNG1F)

Zinc-regulated GTPase metalloprotein activator 1F (ZNG1F) is a member of the COG0523 protein family, functioning as a zinc chaperone that directly transfers zinc to selected metalloproteins, notably methionine aminopeptidase 1 (METAP1) in vertebrates[1][2][7]. ZNG1F catalyzes the transfer of zinc from a high-affinity binding site in its GTPase domain to the active site of METAP1 through a GTP hydrolysis-dependent mechanism, thus enabling the protease to cleave initiator methionine residues from nascent polypeptides during or after translation[2]. The protein is predicted to reside in the cytoplasm and nucleus, and is essential for intracellular zinc homeostasis, especially under conditions of zinc deprivation[1][2]. Mutations in ZNG1 homologs disrupt mitochondrial function and organismal development in animal models, but ZNG1F is not currently described as a validated therapeutic target or associated with any approved drugs[2]. The molecule's alternative names include CBWD6, CBWD7, and COBW domain-containing protein 6[1][7]. Notes on correctness and ambiguity: - There is no established evidence in the literature or curated therapeutic target databases that ZNG1F is a validated drug target, receptor, or transporter (thus, is_target is false)[1][2][7]. - The extensive alias list includes symbols that may reference related/overlapping family members; the most scientifically accurate human gene symbol is ZNG1F, HGNC:31978[1]. - ZNG1F is a specific zinc chaperone, not a receptor or enzyme with classic druggable activity. - No interacting drugs, biomarker roles, or known safety/therapeutic issues are currently described. - If a user expected a receptor or established therapeutic target, this is not the case—thus, is_incorrect = true for a classic drug target context.

Other names

CBWD6CBWD7COBW domain-containing protein 6Cobalamin synthase W domain-containing protein 6Zinc-regulated GTPase metalloprotein activator 1FCOBW domain-containing protein 7Cobalamin synthetase W domain-containing protein 6putative COBW domain-containing protein 7OTTHUMG00000066820OTTHUMG00000067194