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Target intelligence / Profile preview
Zinc ribbon domain-containing protein 2 (ZNRD2)
- Target
- ZNRD2
- Molecular classification
- Other (zinc ribbon domain protein)
01
Overview
Zinc ribbon domain-containing protein 2 (ZNRD2) is a small antigenic protein that may play a role in mitosis and has been proposed as a centromere-associated protein. It is recognized by a subset of anti-centromere antibodies from patients with scleroderma and/or Sjögren’s syndrome but its subcellular localization and precise biological function remain unclear. It is also associated with the disease otosclerosis, but is not established as a drug target or receptor.
- Other names
- SSSCA1p27Autoantigen p27Protein zinc ribbon domain type 2Sjoegren syndrome/scleroderma autoantigen 1Centromeric autoantigen (27kD)
02
Biological functions
Potential centromere associationMay play a role in mitosisIdentical protein binding
03
Disease associations
Autoimmune disease (notably recognized as an autoantigen in scleroderma and Sjögren’s syndrome)Otosclerosis
04
Biomarkers
Centromeric autoantigen for anti-centromere antibody detection in scleroderma or Sjögren's syndrome
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