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Zinc Transporter Isoform ZnT8 (None)
- Target
- None
- Molecular classification
- Transporter, SLC30 family
01
Overview
Zinc transporter 8 (ZnT8), encoded by the SLC30A8 gene, is a member of the SLC30 family of zinc transporters. It functions as a proton-coupled zinc ion antiporter, mediating the entry of zinc into the lumen of pancreatic beta cell secretory granules. This process is essential for insulin storage, maturation, and secretion in pancreatic β-cells. Genetic variants in SLC30A8 are associated with increased or decreased risk of Type 1 and Type 2 Diabetes, with loss-of-function mutations conferring protection against Type 2 Diabetes.
- Other names
- ZnT8SLC30A8
02
Mechanism of action
Modulation of zinc transport into pancreatic beta cell secretory granules.
03
Biological functions
Zinc ion transportInsulin storageInsulin maturationInsulin secretionBlood glucose regulation
04
Disease associations
Type 1 DiabetesType 2 Diabetes
05
Safety considerations
Potential for altered insulin secretion and glucose homeostasis if ZnT8 function is excessively inhibited or enhanced.
06
Biomarkers
R325/W325 variants for T2D risk assessment
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