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Zinc transporter ZIP11 (ZIP11)
- Target
- ZIP11
- Molecular classification
- Transporter, Metal ion transporter, ZIP (Zrt- and Irt-like protein) family, SLC (Solute carrier) family
01
Overview
Zinc transporter ZIP11 (SLC39A11) is a membrane protein within the SLC39 (ZIP) family, responsible for the import of zinc, and also regulates manganese homeostasis in vertebrates[4][5]. ZIP11 is localized to the plasma membrane, nucleus, cytoplasm, and Golgi apparatus[3][1]. It is highly expressed in the stomach and colon, especially in mucosal and parietal cells, and its levels respond to dietary zinc and manganese exposure[1][4]. ZIP11 helps maintain cellular and nuclear zinc levels, which are critical for cellular integrity, cell cycle regulation, and possibly processes related to aging and longevity[1][4]. Genetic variation in SLC39A11 is associated with differences in lifespan and susceptibility to several cancers[4]. Its precise transport mechanism, substrate specificity (for zinc, manganese, copper), and potential as a therapeutic target require further research, but its role in metal homeostasis and disease is established[1][4][3].
- Other names
- SLC39A11Solute carrier family 39 member 11ZIP-11Zrt- and Irt-like protein 11C17orf26
02
Biological functions
Regulation of zinc homeostasisRegulation of manganese homeostasisCellular metal ion transportMaintaining cytosolic and nuclear zinc levelsPossible copper ion transportInfluence on cell cycle and mucosal integrity
03
Disease associations
Cancer (including bladder, glioma, colorectal, pancreatic, lung)Aging and longevityPotential associations with Brown-Vialetto-Van Laere Syndrome 2
04
Safety considerations
Potential impact on systemic metal (zinc, manganese) concentrations in knockout or inhibited statesNo evidence of central nervous manganese accumulation or parkinsonism in SLC39A11 knockout models, but other systemic changes possible
05
Biomarkers
SNPs in SLC39A11 associated with longevity in male centenariansAltered expression in aging, cancer, and dietary zinc/manganese deficiency
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