Zinc transporter ZIP2 (ZIP2)

Zinc transporter ZIP2 (SLC39A2) is a member of the solute carrier family 39 of membrane transporters, specifically the ZIP (Zrt/Irt-like protein) family, responsible for mediating the cellular uptake of zinc and other divalent metal ions from the extracellular environment into the cytoplasm[1][2][3]. SLC39A2 is predicted to have eight transmembrane domains with both termini facing the extracellular side[1][2]. It is widely expressed, with notably high expression in prostate and uterine epithelial cells[2]. ZIP2 primarily transports zinc (Zn²⁺), but can also transport cadmium (Cd²⁺), copper (Cu²⁺), and cobalt (Co²⁺), in order of decreasing affinity; it does not transport iron (Fe²⁺)[2][3]. Transport activity is modulated by extracellular pH and membrane potential, but is independent of ATP and sodium or potassium gradients[1][3][4]. Mutations in SLC39A2 are associated with susceptibility to carotid artery disease, and ZIP2 plays a role in epidermal keratinocyte differentiation[3]. ZIP2's biological relevance is tied to maintaining proper cellular zinc levels, essential for numerous cellular processes and enzymatic activities[1][2].

Other names

SLC39A2ZIP-2hZIP26A1Eti-1Solute carrier family 39 member 2Zrt- and Irt-like protein 2zinc transporter 2ZRT/IRT-like protein 2zinc uptake transporter 2ETI-1

Modulation of zinc influx and intracellular zinc homeostasis; Divalent cation symport (Zn²⁺, Cd²⁺, Cu²⁺, Co²⁺); Electrochemical modulation and pH-dependent transport[1][4]