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Target intelligence / Profile preview
Zn-regulated GTPase metalloprotein activator 1A (ZNG1A)
- Target
- ZNG1A
- Molecular classification
- GTPase, Metallochaperone, Enzyme (zinc chaperone activity), member of the COG0523 protein family
01
Overview
Zn-regulated GTPase metalloprotein activator 1A (ZNG1A) is a vertebrate protein functioning as a metallochaperone within the COG0523 family of GTPases. It has GTPase and zinc chaperone activities and is functionally required for maintaining cellular zinc homeostasis by facilitating the intracellular allocation and trafficking of zinc ions to specific zinc metalloproteins, such as methionine aminopeptidase 1 (METAP1). ZNG1A is widely expressed in tissues, including the kidney, and is subcellularly localized to the nucleus. While not a direct pharmacological target, ZNG1A is essential for zinc-dependent biological processes, especially under conditions of zinc limitation, and may play broad roles in vertebrate zinc physiology.
- Other names
- CBWD1COBW domain-containing protein 1NPC-A-6Cobalamin synthase W domain-containing protein 1COBPZinc-regulated GTPase metalloprotein activator 1A (full name)COBW domain containing 1COBW-like protein
02
Biological functions
Cellular zinc homeostasisIntracellular zinc traffickingGTP hydrolysisMetallochaperoning specific metalloenzymes (notably methionine aminopeptidase 1, METAP1)
03
Disease associations
Other (no direct disease associations; implied relevance to conditions involving zinc metabolism or homeostasis, such as nutritional deficiencies or rare hereditary disorders)
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