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ZNF225 and ZNF224 antisense RNA 1 (ZNF225-AS1)
- Target
- ZNF225-AS1
- Molecular classification
- Long non-coding RNA (lncRNA), Antisense RNA
01
Overview
ZNF225 antisense RNA 1 (ZNF225-AS1) is a long non-coding antisense RNA transcript that overlaps the ZNF225 and ZNF224 gene loci on chromosome 19. It does not encode a protein and is thought to regulate nearby gene expression by mechanisms typical of antisense RNAs, such as transcriptional interference, chromatin remodeling, and modulation of alternative splicing. ZNF225-AS1 is associated with Alzheimer's disease in genetic association studies, but its molecular function and disease mechanisms are not yet fully established. There are currently no known drugs or therapeutic interventions directly targeting ZNF225-AS1.
- Other names
- ZNF225-AS1ZNF225 and ZNF224 antisense RNA 1HGNC:55916NCBI Gene:100379224Ensembl:ENSG00000186019
02
Biological functions
Regulation of gene expression (cis and trans)Epigenetic modulationMay influence transcription, splicing, and chromatin structure (by analogy to other antisense RNAs)
03
Disease associations
Alzheimer's disease (association found in GWAS)Potential roles in cancer and other epigenetic diseases (not yet validated for ZNF225-AS1 specifically; inferred from antisense RNA family)
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