ZNF286A-TBC1D26 readthrough (ZNF286A-TBC1D26)

ZNF286A-TBC1D26 readthrough refers to a naturally occurring transcript where transcription continues from the end of the ZNF286A gene into the neighboring TBC1D26 gene, creating a hybrid RNA molecule. This transcript is classified as a readthrough product and is currently thought to be non-coding, subject to nonsense-mediated decay (NMD), and does not encode any known functional protein[3]. It is a naturally occurring RNA transcript resulting from transcription that proceeds through the boundary of the ZNF286A and TBC1D26 genes. It is characterized as non-coding and is a candidate for nonsense-mediated mRNA decay (NMD), meaning the transcript is likely to be degraded by cellular surveillance mechanisms and does not encode a functional protein. GeneCards, RefSeq, and other databases classify this readthrough locus as affiliated with the ncRNA class and highlight that it does not produce a protein product nor is it currently associated with any biological functions, disease roles, or therapeutic relevance[3]. The formation of this readthrough transcript is a phenomenon seen in human genomes, often resulting in non-functional or regulatory RNA species. There is no evidence that the ZNF286A-TBC1D26 readthrough transcript functions as a receptor, enzyme, transporter, or any classic target class for drug development, and it is not used as a biomarker or target in therapeutic contexts[3].

Other names

ZNF286A-TBC1D26 Readthrough (NMD Candidate)ZNF286A-TBC1D26 RNA