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Target intelligence / Profile preview
ZNF385D antisense RNA 2 (ZNF385D-AS2)
- Target
- ZNF385D-AS2
- Molecular classification
- Long non-coding RNA (lncRNA), Other (Antisense RNA)
01
Overview
ZNF385D antisense RNA 2 (ZNF385D-AS2) is a long non-coding RNA gene located on chromosome 3 (chr3:21942566-21979828, human genome hg38). It is transcribed in the antisense direction relative to the ZNF385D gene. ZNF385D-AS2 is predicted to have regulatory functions, potentially influencing gene expression networks in cancer. Studies show that low levels of ZNF385D-AS2 are significantly associated with advanced clinical stage and poor prognosis in liver cancer (specifically hepatocellular carcinoma), and may act as an independent prognostic biomarker. The biological mechanism may involve ceRNA interactions with miR-96 and miR-182, but direct therapeutic intervention has not yet been explored.
- Other names
- ZNF385D-AS2ZNF385D antisense RNA 2 (non-protein coding)
02
Mechanism of action
Not applicable; no drugs directly targeting ZNF385D-AS2 exist. Its mechanism of action may involve ceRNA/microRNA (miRNA) regulatory axes, e.g., as a competing endogenous RNA for miR-96 and miR-182
03
Biological functions
Regulation of gene expression (potential regulatory role on ZNF385D and other nearby genes)May be involved in cell proliferation and survival pathways in cancer (as inferred from correlations with prognosis in hepatocellular carcinoma)
04
Disease associations
Cancer (particularly hepatocellular carcinoma, based on expression and prognosis links)Potentially other diseases per predicted function, but currently best studied in cancer
05
Biomarkers
ZNF385D-AS2 expression is a prognostic biomarker in hepatocellular carcinoma: low expression is associated with poor prognosis and reduced overall survival
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