ZNF561 antisense RNA 1 (ZNF561-AS1)

ZNF561 antisense RNA 1 is a long non-coding RNA located on human chromosome 19p13.2. It does not encode a protein, but regulates gene expression post-transcriptionally. In colorectal cancer, ZNF561-AS1 is overexpressed and acts as an oncogenic factor by sequestering miR-26a-5p and miR-128-3p, thereby promoting the upregulation of SRSF6, a serine-arginine-rich splicing factor. This stimulates cell proliferation, supports cell cycle progression, and suppresses apoptosis in cancer cells. ZNF561-AS1 may have tissue-specific roles, functioning as a tumor promoter in some contexts and a suppressor in others. No direct pharmacological agents currently target ZNF561-AS1, but its expression level is being explored as a biomarker and its inhibition represents a potential therapeutic strategy for cancers exhibiting dysregulation of this lncRNA

Other names

ZNF561 antisense RNA 1ZNF561-AS1C19orf82ZNF561 antisense gene protein 1ZNF561 antisense RNA 1 (head-to-head)uncharacterized protein C19orf82

Inhibition of lncRNA-mediated miRNA sponging, suppressing downstream oncogenic pathways