ZNRF2-LINC01176 readthrough

ENSG00000281593 corresponds to a "readthrough" transcript joining the **ZNRF2** gene (an E3 ubiquitin ligase regulating mTORC1 signaling and lysosomal function[1][2]) and **LINC01176** (a long non-coding RNA). Readthrough transcripts usually result from transcription extending from one gene into an adjacent gene and are often products of aberrant transcription or incomplete annotation, not established protein-coding or functional biological molecules. This entity is not recognized as a canonical protein or therapeutic target, does not have characterized molecular classification, biological function, or disease role, and has no established pharmacology or biomarker utility[3]. The relevant canonical proteins are ZNRF2 and, separately, LINC01176. **Note:** All functional and disease-related literature concerns ZNRF2, not the "ZNRF2-LINC01176 readthrough" product. For research on targets with therapeutic potential, refer to ZNRF2, not the readthrough transcript.