Zona pellucida-like domain-containing protein 1 (ZPLD1)

Zona pellucida-like domain-containing protein 1 (ZPLD1, also known as cupulin) is a highly conserved, secreted glycoprotein characterized by the presence of a zona pellucida-like domain, a structural motif central to its role in matrix assembly[2][4][5]. In vertebrates, ZPLD1 is a major constituent of the cupula, a gelatinous structure that overlays the crista ampullaris in the semicircular canals of the inner ear, critical for detecting rotational head movements and maintaining balance[2][4]. In mice, loss-of-function mutations in Zpld1 result in pronounced vestibular deficits without affecting cochlear or otolithic organ functions, implicating ZPLD1 as an essential structural component of the vestibular apparatus[2]. While its homologs and family share roles in various extracellular matrices, there are no current reports of ZPLD1 acting as a disease gene or as a direct clinical target in humans[2][4][6].

Other names

CupulinZP domain-containing protein 1zona pellucida-like domain-containing protein 1ZPLD1cupulin