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Target intelligence / Profile preview
Zonulin
- Molecular classification
- Other, Protein
01
Overview
Zonulin is a human protein that regulates the permeability of tight junctions between cells in the intestinal epithelium. It is the only known physiological modulator capable of reversibly controlling intestinal permeability. Elevated zonulin levels are associated with increased intestinal permeability and autoimmune diseases. It is considered a therapeutic target for diseases involving increased intestinal permeability.
- Other names
- Pre-haptoglobin 2pre-HP2
02
Mechanism of action
Zonulin inhibitors reduce intestinal permeability by preventing zonulin-mediated tight junction disassembly.
03
Biological functions
Regulation of intestinal permeabilityTight junction modulationBarrier integrity
04
Disease associations
Celiac diseaseType 1 diabetesType 2 diabetesAutoimmune diseasesMetabolic disordersInflammatory bowel conditionsLeaky gut syndrome
05
Safety considerations
Potential disruption of normal barrier function with excessive inhibitionUnknown long-term effects of zonulin modulation
06
Interacting drugs
Larazotide acetate
07
Biomarkers
Fecal zonulinSerum zonulin
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