ZRSR2 pseudogene 1 (ZRSR2P1)

ZRSR2 pseudogene 1 (ZRSR2P1) is a noncoding pseudogene in humans, derived from retrotransposition of the functional ZRSR2 gene, and does not encode a functional protein[1][4][5]. In humans, ZRSR2P1 is designated as a pseudogene and does not appear to be expressed at notable levels or to have biological activity. Functional splicing activity related to U12-type introns is carried out by the canonical ZRSR2 protein and, in some species (such as mouse), by a functional retrocopy Zrsr1[1]. In contrast, the human ZRSR2P1 does not contribute to splicing and is widely considered nonfunctional. It is not regarded as a therapeutic target and has no known disease association or drug interactions. Key clarifications: This entity is a pseudogene (non-functional gene); in human tissues, it produces neither protein nor biological activity[1][4][5]. The functional gene is ZRSR2, which is essential for minor (U12-type) spliceosome function. In mice, Zrsr1 (the homologous retrogene) can be functional, but this does not apply to human ZRSR2P1[1]. No drugs, disease associations, or biomarker roles are known for ZRSR2P1. Summary: ZRSR2 pseudogene 1 (ZRSR2P1) is a non-functional, non-coding pseudogene in humans and should not be considered a drug target or functional gene. Its nomenclature frequently overlaps with other functional spliceosomal proteins, causing confusion, but the human ZRSR2P1 does not encode a protein or participate in mRNA processing[1][4][5].

Other names

U2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 1ZRSR2P1U2AF1-RS1U2AF1L1U2AF1PU2AF1RS1U2AFBPLZRSR1ZC3H21CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 1U2(RNU2) small nuclear RNA auxiliary factor 1-like 1U2(RNU2) small nuclear RNA auxiliary factor pseudogene 1zinc finger (CCCH type), RNA binding motif and serine/arginine rich 1zinc finger CCCH-type, RNA binding motif and serine/arginine rich 1